Melanie L Lehman Selected Research

eusynstyelamide B

12/2015

The ascidian natural product eusynstyelamide B is a novel topoisomerase II poison that induces DNA damage and growth arrest in prostate and breast cancer cells.

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Melanie L Lehman Research Topics

Disease

15	Prostatic Neoplasms (Prostate Cancer) 01/2020 - 02/2010
15	Neoplasms (Cancer) 01/2020 - 02/2010
2	Neoplasm Metastasis (Metastasis) 01/2019 - 07/2015
1	Hypersensitivity (Allergy) 01/2020
1	Disease Progression 01/2019
1	Breast Neoplasms (Breast Cancer) 12/2015

Drug/Important Bio-Agent (IBA)

11	AndrogensIBA 01/2020 - 02/2010
5	Androgen Receptors (Androgen Receptor)IBA 01/2020 - 02/2010
3	enzalutamideIBA 01/2020 - 12/2015
3	Hormones (Hormone)IBA 01/2019 - 12/2011
3	Proteins (Proteins, Gene)FDA Link 01/2019 - 10/2013
3	Insulin (Novolin)FDA Link 01/2019 - 07/2010
3	Pharmaceutical PreparationsIBA 12/2017 - 01/2012
2	LipidsIBA 01/2020 - 01/2019
2	Peptide Hydrolases (Proteases)FDA Link 01/2020 - 09/2014
2	SteroidsIBA 01/2019 - 02/2010
2	Transcription Factors (Transcription Factor)IBA 01/2019 - 10/2013
2	Fatty Acids (Saturated Fatty Acids)IBA 01/2019 - 02/2010
2	RNA (Ribonucleic Acid)IBA 12/2017 - 12/2015
2	Biological ProductsIBA 12/2015 - 06/2014
2	Mechanistic Target of Rapamycin Complex 1IBA 07/2015 - 12/2011
2	Amino Acids FDA Link 10/2013 - 12/2011
1	Glutathione PeroxidaseIBA 01/2020
1	IronIBA 01/2020
1	Kallikreins (Kallikrein)IBA 01/2020
1	Unsaturated Fatty Acids (Polyunsaturated Fatty Acids)IBA 01/2020
1	Serine Proteases (Serine Protease)IBA 01/2020
1	Insulin ReceptorIBA 01/2019
1	CholesterolIBA 01/2019
1	LDL Lipoproteins (beta Lipoproteins)IBA 01/2019
1	Messenger RNA (mRNA)IBA 01/2019
1	ProteomeIBA 01/2019
1	Long Noncoding RNAIBA 12/2017
1	eusynstyelamide BIBA 12/2015
1	Type II DNA Topoisomerases (Topoisomerase II)IBA 12/2015
1	PoisonsIBA 12/2015
1	bicalutamide (Casodex)FDA LinkGeneric 12/2015
1	NitrogenIBA 07/2015
1	CarbonIBA 07/2015
1	Small Interfering RNA (siRNA)IBA 07/2015
1	E2F Transcription FactorsIBA 07/2015
1	Glutamine (L-Glutamine)FDA Link 07/2015
1	Tricarboxylic AcidsIBA 07/2015
1	Indicators and Reagents (Reagents)IBA 09/2014
1	TOR Serine-Threonine KinasesIBA 10/2013
1	GhrelinIBA 04/2013
1	Extracellular Matrix ProteinsIBA 01/2012
1	aspartic acid glycine arginineIBA 01/2012
1	Matrix Metalloproteinases (MMPs)IBA 01/2012
1	HydrogelsIBA 01/2012
1	Polyethylene Glycols (Polyethylene Glycol)FDA LinkGeneric 01/2012
1	Leucine (L-Leucine)FDA Link 12/2011
1	Essential Amino AcidsIBA 12/2011
1	Amino Acid Transport Systems (Amino Acid Transporter)IBA 12/2011
1	Metalloproteases (Metalloproteinases)IBA 07/2010
1	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 07/2010
1	Peptide Hormones (Polypeptide Hormones)IBA 07/2010
1	Nitric Oxide (Nitrogen Monoxide)FDA Link 07/2010
1	RelaxinIBA 07/2010
1	Arachidonic Acid (Vitamin F)IBA 02/2010

Therapy/Procedure

5	Therapeutics 01/2020 - 07/2010
2	Castration 10/2013 - 02/2010